Port Moresby General Hospital is located in the capital city of Port Moresby and is the major referral and teaching hospital in Papua New Guinea. It is also a centre for AIDS treatment in Papua New Guinea, one of only a few facilities in the country equipped to treat HIV/AIDS and also houses a hyperbaric recompression chamber for diving emergencies. The hospital is the only hospital in the country to have a CT scanner, and the expense of travel to the capital means that not all of the population can take advantage of the facilities offered by the hospital.

The AIDS team at the hospital has functioned as a pilot programme for AIDS care in Papua New Guinea and consists of 15 healthcare professionals including doctors, nurses, a lab technician, and a counsellor. AIDS remains the most common cause of death at Port Moresby General, accounting for 24 percent of total mortality at the hospital.